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PubMed Vif vif HIV-1 Vif binds on the mobile cytidine deaminase APOBEC3G and targets it for degradation by an interaction With all the proteasome, thus inhibiting APOBEC3G mediated restriction of HIV-1 replication

An important function of the modified proteasome, the immunoproteasome, may be the processing of course I MHC peptides. This gene encodes a member in the proteasome B-style relatives, often known as the T1B check here family, That could be a 20S core beta subunit. Proteolytic processing is needed to generate a experienced subunit. Expression of the gene is induced by gamma interferon, which gene product replaces catalytic subunit 2 (proteasome beta seven subunit) within the immunoproteasome. [furnished by RefSeq, Jul 2008]

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Diminished contamination usually means a small drift amount—even immediately after hrs of use in metal-block furnaces at higher temperatures.

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